Sabita Chourasia

Sabita Chourasia, PhD

Post Doctoral Fellow

Prof. Atan Gross Research Group
Department of Immunology and Regenerative Biology
Candiotty Building, Room no.223
Weizmann Institute of Science, Rehovot, Israel

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Dr. Sabita Chourasia

Postdoctoral Researcher, Department of Immunology & Regenerative Biology, Weizmann Institute of Science

About

Dr. Sabita Chourasia is a postdoctoral researcher at the Weizmann Institute of Science, affiliated with the Department of Immunology and Regenerative Biology. Her work focuses on mitochondrial metabolism, specifically the role of the MTCH2 protein in energy regulation and adipocyte differentiation. Her research has significant implications for understanding and potentially treating obesity.

Research Interests: MTCH2 proteinEnergy regulationAdipocyte differentiationObesity research implications

Profiles & Resources

Published Research Articles

MTCH2 controls energy demand and expenditure to fuel anabolism during adipogenesis

Published in EMBO Journal, January 2025

This study demonstrates that deletion of the MTCH2 gene leads to increased mitochondrial oxidative function and energy demand, creating a catabolic environment that impedes adipocyte differentiation.

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High-energy demand and nutrient exhaustion in MTCH2 knockout cells

Preprint on bioRxiv, December 2023

This research reveals that MTCH2 deletion results in high ATP demand and oxidative stress, leading to impaired adipogenesis due to an energy-deficient environment.

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News Coverage of Research Work

"Slimming with Mitch" – Weizmann Wonder Wander

Featured on Weizmann Wonder Wander

An article discussing the potential of targeting MTCH2 for obesity treatment, highlighting Dr. Chourasia’s contributions.

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Blocking MTCH2 to prevent fat accumulation – Medical Xpress

Covered by Medical Xpress

Coverage on how blocking the MTCH2 protein can prevent fat accumulation in human cells, referencing Dr. Chourasia’s study.

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Effects of MTCH2 deletion on cellular metabolism – Technology Networks

Article by Technology Networks

Details the effects of MTCH2 deletion on cellular metabolism and its implications for obesity research.

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MTCH2-targeted therapies and “immunity” to obesity – LADbible

Featured on LADbible

A piece discussing the potential of MTCH2-targeted therapies in making humans “immune to obesity,” citing Dr. Chourasia’s work.

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